Sanford USD Medical Center is a hospital in Sioux Falls, South Dakota, US. It is operated by Sanford Health system. It is a Level II Trauma Center. It is the largest hospital in South Dakota. It was ranked as one of the 100 Great Hospitals in America by Becker's Hospital Review in 2017 and 2018. Sanford University of South Dakota Medical Center is the largest tertiary hospital in South Dakota.